Polymethylmethacrylate particles stimulate bone resorption of mature osteoclasts in vitro
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چکیده
منابع مشابه
Androgens regulate bone resorption activity of isolated osteoclasts in vitro.
For many years it has been recognized that sex steroids have profound effects on bone metabolism. The current perception is that estrogen decreases bone resorption and androgen increases bone deposition. To investigate the potential for androgens to directly modulate bone resorption, we have examined avian osteoclast and human and mouse osteoclast-like cells for androgen responsiveness. There w...
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We investigated in vitro a mechanism by which particulate debris may induce bone resorption and cause implant loosening. We first studied two standard particles: latex, which is considered to be inert, and zymosan, which is inflammatory. Macrophages that phagocytosed either particle became activated, and stimulated 15 times as much bone resorption as did control macrophages. For activation to o...
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A carborundum wheel was used to prepare slices of cortical bone that demonstrate a predictable surface appearance in the scanning electron microscope. Osteoclasts were mechanically disaggregated from neonatal rabbit long bones and settled onto these slices. After 24h in culture osteoclasts were associated with areas of excavation in the bone surface. These excavated areas typically showed a wel...
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The mechanisms by which bone resorbing osteoclasts form and are activated by hormones are poorly understood. We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects seen when bones are treated with hormones such as parathyroid hormone (PTH) and interleukin 1 (IL-1...
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Bisphosphonates are useful in treatment of disorders with increased osteoclastic activity, but the mechanism by which bisphosphonates act is unknown. We used cultures of chicken osteoclasts to address this issue, and found that 1-hydroxyethylidenediphosphonic acid (EHDP), dichloromethylidenediphosphonic acid (Cl2MDP), or 3-amino-1-hydroxypropylidene-1,1-diphosphonic acid (APD) all cause direct ...
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ژورنال
عنوان ژورنال: Acta Orthopaedica
سال: 2008
ISSN: 1745-3674,1745-3682
DOI: 10.1080/17453670710015166